Understanding Ankle Pain: Causes, Diagnosis, and Treatment
Ankle pain can result from various issues, including acute injuries, arthritis, or everyday wear and tear on the bones, muscles, cartilage, ligaments, or tendons. Common symptoms are sudden pain, swelling, redness, and discomfort when bearing weight. The ankle might also feel stiff or appear deformed.
To determine the cause of your ankle pain, it’s important to consult a healthcare provider. They can perform a physical examination and may recommend imaging studies such as X-rays or CT scans. Blood tests might also be conducted to check for inflammation, infections, or autoimmune conditions like rheumatoid arthritis.
Here’s an overview of common and rare causes of ankle pain, along with their diagnosis and treatment.

Anatomy of the Ankle
The ankle is crucial for balance and movement, enabling activities like walking, running, and jumping. It consists of:
- Bones: The talus connects with the tibia and fibula to form the ankle joint.
- Ligaments: These stabilize the bones.
- Muscles: Control movements such as rotation and lifting the toes towards the shin (dorsiflexion) or pointing them away (plantarflexion).
- Nerves: The tibial and peroneal nerves manage muscle movement and sensation.
- Tendons: Connect muscles to bones.
- Joints: Include the talocrural (for dorsiflexion and plantarflexion), subtalar (for foot rotation), and inferior tibiofibular (to prevent excessive rotation or flexion).
- Cartilage: Covers joint surfaces for smooth movement.
- Synovial Fluid: Lubricates the joints.
- Bursa: Fluid-filled cushions that reduce friction.
Injuries to any of these components can cause pain, often involving multiple structures. Risk factors include age, weight, obesity, and sports with jumping or sharp turns.
Common Causes of Ankle Pain
- Sprains: Ligaments are stretched or torn, often from stepping off a curb or playing sports. Types include:
- Anterior Talofibular Ligament Sprain: Most common, causing pain, swelling, bruising, and instability.
- Medial Sprains: Affect ligaments on the inside of the ankle, usually from rolling the ankle outward.
- High Ankle Sprains: Pain above the ankle where the lower leg bones connect, common in impact sports.
- Tendonitis: Inflammation of tendons, including:
- Peroneal Tendonitis: Causes dull ache or popping on the outer ankle, worsened by activity.
- Posterior Tibial Tendonitis: Pain and swelling on the inner ankle, often gradually.
- Achilles Tendonitis: Burning pain at the back of the ankle, common in sports with quick movements.
- Arthritis: Includes:
- Osteoarthritis: Wear and tear of cartilage, leading to pain and stiffness.
- Rheumatoid Arthritis: Autoimmune condition causing bilateral pain and swelling.
- Post-Traumatic Arthritis: Develops after an injury, similar to osteoarthritis.
- Bone Breaks: Fractures in the tibia, fibula, or talus, usually from twisting or rolling the ankle. Symptoms include severe pain, swelling, bruising, and difficulty bearing weight.
- Bone Bruises: Less severe than fractures but can cause significant pain and swelling.
Uncommon Causes of Ankle Pain
- Gout: Inflammatory arthritis from uric acid crystals, causing red, tender, and swollen joints.
- Bursitis: Inflammation of bursae, leading to pain and swelling, often from overuse or poor-fitting shoes.
- Osteomyelitis: Bone infection causing pain, warmth, and swelling.
- Tarsal Tunnel Syndrome: Nerve compression in the ankle causing aching, burning, or tingling.
- Peroneal Neuropathy: Compression of the peroneal nerve causing pain and tingling along the ankle.
- Tumors: Both benign and malignant tumors, including synovial cysts and chondrosarcoma.
Diagnosing Ankle Issues
Diagnosis typically involves reviewing your medical history, a physical exam, and imaging tests. Here’s what to expect:
Medical History: Provide detailed information about your pain location, type, duration, onset, and any additional symptoms.
Physical Examination:
- Ottawa Ankle Rules: Assess tenderness around the malleoli or inability to bear weight to determine if X-rays are needed.
- Talar Tilt Test: Evaluates ankle laxity to diagnose ligament sprains.
- Squeeze Test: Checks for high ankle sprains by compressing the lower leg bones.
Imaging:
- X-rays: Help distinguish between sprains and fractures.
- CT or MRI: Used for complex diagnoses or to assess soft tissue injuries.
- Nerve Conduction Studies or EMG: May be required for nerve issues.
Differential Diagnoses: Sometimes ankle pain may be due to conditions not directly related to the ankle, such as:
- Deep Vein Thrombosis: Blood clot causing swelling and pain.
- Cellulitis: Skin infection spreading to deeper tissues.
- Lumbar Radiculopathy: Nerve pain radiating from the lower back.
- Acute Compartment Syndrome: Severe pressure build-up in muscles.
Treatment for Ankle Pain
Treatment depends on the cause, but a common initial approach is the RICE protocol:
- Rest: Allows inflammation to subside.
- Ice: Reduces swelling and pain (15-20 minutes, several times a day).
- Compression: Supports and immobilizes the ankle.
- Elevation: Helps decrease swelling by raising the ankle.
Physical Therapy: Often recommended for strengthening, improving mobility, and reducing stiffness. Supports such as crutches, braces, orthotics, or casts may be used.
Medications:
- NSAIDs: For pain and inflammation (e.g., ibuprofen).
- Opioids: Short-term use for severe pain (e.g., hydrocodone).
- Cortisone Shots: For chronic conditions when other treatments fail.
Surgery: May be necessary for severe cases:
- Debridement: Removing damaged tissues or bone spurs.
- Arthrodesis: Fusing bones to reduce joint movement.
- Total Ankle Replacement: Replacing the damaged joint with an artificial implant.
When to See a Healthcare Provider
Consult a healthcare provider if you experience:
- Inability to walk or visible deformity.
- Pain that worsens at night or doesn’t improve.
- Persistent swelling or inability to bend the ankle.
- Signs of infection (fever, redness, warmth) or any unusual symptoms.
Preventing Ankle Pain
To reduce the risk of ankle injuries:
- Warm up before physical activity.
- Wear appropriate footwear for your activity.
- Listen to your body: stop or slow down if you experience pain.
- Maintain a healthy weight and consider low-impact activities if you have ankle problems.
Summary
Ankle pain can result from acute injuries, chronic conditions, or other underlying issues. A healthcare professional will typically perform a physical exam and may use imaging or blood tests to diagnose the problem. Treatment ranges from self-care measures like RICE to medications, physical therapy, and possibly surgery.